The game takes place in Pacific City, a dystopian metropolis that is suffering from an increase in crime rate. Criminal syndicates - namely Los Muertos, The Volk, and The Shai-Gen Corporation - have taken control of its three main territories, and they are armed with military-grade weapons that make it difficult for law enforcement to combat them. A secret organization known as the Agency took it upon themselves to eliminate the city's organized crime using their wide resources and genetically modified human beings called Agents. The Agent successfully brought down each criminal syndicates but it was later found out that it was the Agency itself who supplied the criminals with weapons. They planned for the city to go down in anarchy so that they can step in, stop the criminals and be hailed heroes when they themselves take over.