Xenoblade Chronicles

In Xenoblade Chronicles you're quickly introduced to a cast of energetically animated characters sporting unnatural hair colors and bizarre outfits before setting out learning an elaborate real-time melee combat system, the intricacies of which will take most players dozens of hours to fully comprehend and master.
Its wildly imaginative plot, which features a small population of humanoids living upon the massive body of a fallen god while fighting off murderous mechanical invaders, is decidedly within the domain of inspired Japanese fantasy.
However, things eventually take on a more Western flavor. Players get to journey across a massive, free-to-roam world, engaging in literally hundreds of side quests along the way.
Plus, a complex and dynamic social system allows players to interact with and alter their relationships with not just fellow party members, but also secondary characters scattered throughout the world.
It's an enormous game. Dedicated players can expect in excess of 100 hours of play time.